Weria Pezeshkian bio photo

Computational microscopy group at the Niels Bohr International Academy, Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark.

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2026

  • Gerhards, Luca, Hungerland, Jonathan, Schuhmann, Fabian, Kostritski, Andrei Y., Bacic, Vladimir, Geiger, Beatrice, et al.. Multiscale Modeling Approaches in Biomolecular Physics. Advances in Physics X, 2026.
  • Thornburg, Zane R., Maytin, Andrew, Kwon, Jiwoong, Brier, Troy A., Gilbert, Benjamin R., Fu, Enguang, et al.. Bringing the Genetically Minimal Cell to Life on a Computer in 4D. Cell, 2026.
  • Geiger, Beatrice J., Pezeshkian, Weria. Bimodal Mechanical Response of Membrane Necks: Implications for the Nuclear Envelope. ACS Nano, 20, pp. 225–239, 2026.

2025

  • Schuhmann, Fabian, Stevens, Jan A., Rahmani, Neda, Lindahl, Isabell, Brown, Chelsea M., Brasnett, Christopher, et al.. TS2CG as a membrane builder. J. Chem. Theory Comput., 21, pp. 9136–9146, 2025.
  • Vidal, Adria Bravo, Pezeshkian, Weria. Multi-body Fluctuation-Induced Forces Between Membrane Proteins: Insights from Mesoscale Simulations. bioRxiv, 2025. DOI
  • Schuhmann, Fabian, Akkaya, Kerem C., Puchkov, Dmytro, Hohensee, Svea, Lehmann, Martin, Liu, Fan, et al.. Integrative Molecular Dynamics Simulations Untangle Cross-Linking Data to Unveil Mitochondrial Protein Distributions. Angewandte Chemie International Edition, 64, pp. e202417804, 2025.
  • Maurer, Valentin J., Siggel, Marc, Jensen, Rasmus K., Mahamid, Julia, Kosinski, Jan, Pezeshkian, Weria. Helfrich Monte Carlo Flexible Fitting: physics-based, data-driven cell-scale simulations. bioRxiv, 2025. DOI
  • Kapadia, Akshay B., Schuhmann, Fabian, Daskin, Ezgi, Walter, Jochen, Lindahl, Isabell, Rahmani, Neda, et al.. Amyloidogenic proteolysis of APP regulates glutamatergic presynaptic function. bioRxiv, 2025. DOI

2024

  • Cornet, Julie, Coulonges, Nelly, Pezeshkian, Weria, Penissat-Mahaut, Maël, Desgrez-Dautet, Hermes, Marrink, Siewert J., et al.. There and back again: bridging meso-and nanoscales to understand lipid vesicle patterning. Soft Matter, 20, pp. 4998–5013, 2024.
  • Klenow, Martin Berg, Vigsø, Magnus Staal, Pezeshkian, Weria, Nylandsted, Jesper, Lomholt, Michael Andersen, Simonsen, Adam Cohen. Shape of the membrane neck around a hole during plasma membrane repair. Biophysical Journal, 123, pp. 1827–1837, 2024.
  • Schuhmann, Fabian, Bordallo, H. N., Pezeshkian, Weria. Physics-Based Protein Networks Might Recover Effectful Mutations—a Case Study on Cathepsin G. The Journal of Physical Chemistry B, 128, pp. 10043–10050, 2024.
  • Pezeshkian, Weria, Ipsen, John H.. Mesoscale simulation of biomembranes with FreeDTS. Nature Communications, 15, pp. 548, 2024.
  • Pandey, M. P., de Souza, P. C. T., Pezeshkian, W., Khandelia, H.. Bending of a Lipid Membrane Edge by Annexin A5 Trimers. Biophysical Journal, 123, pp. 1006–1014, 2024.

2023

  • Pezeshkian, Weria, Grunewald, Fabian, Narykov, Oleksandr, Lu, Senbao, Wassenaar, Tsjerk, Marrink, Siewert J., et al.. Molecular architecture and dynamics of SARS-CoV-2 envelope by integrative modeling. Structure, 31, pp. 492–503, 2023.
  • Duncan, Anna, Pezeshkian, Weria. Mesoscale simulations: an indispensable approach to understand biomembranes. Biophysical Journal, 122, pp. 1883–1889, 2023.
  • Nonn, Aida, Kiss, Bálint, Pezeshkian, Weria, Tancogne-Dejean, Thomas, Cerrone, Albert, Kellermayer, Miklos, et al.. Inferring mechanical properties of the SARS-CoV-2 virus particle with nano-indentation tests and numerical simulations. Journal of the mechanical behavior of biomedical materials, 148, pp. 106153, 2023.
  • König, Melanie, de Vries, Reinier, Grünewald, Fabian, Marrink, Siewert J., Pezeshkian, Weria. Curvature-induced lipid sorting beyond the critical packing parameter. bioRxiv, 2023. DOI
  • Ruhoff, V. T., Bendix, P. M., Pezeshkian, W.. Close, but not too close: a mesoscopic description of (a) symmetry and membrane shaping mechanisms. Emerging Topics in Life Sciences, 7, pp. 81–93, 2023.
  • De Franceschi, Nicola, Pezeshkian, Weria, Fragasso, Alessio, Bruininks, Bart, Tsai, Sean, Marrink, Siewert J., et al.. A synthetic membrane shaper for controlled liposome deformation. ACS Nano, 17, pp. 966–978, 2023.

2022

  • Ruhoff, Victoria Thusgaard, Moreno-Pescador, Guillermo, Pezeshkian, Weria, Bendix, Poul Martin. Strength in numbers: effect of protein crowding on the shape of cell membranes. Biochem. Soc. Trans., 50, pp. 1257–1267, 2022.
  • Grünewald, Fabian, Punt, Mats H., Jefferys, Elizabeth E., Vainikka, Petteri A., König, Melanie, Virtanen, Valtteri, et al.. Martini 3 Coarse-Grained Force Field for Carbohydrates. J. Chem. Theory Comput., 18, pp. 7555–7569, 2022.

2021

  • Pezeshkian, Weria, Marrink, Siewert J.. Simulating Realistic Membrane Shapes. Current Opinion in Cell Biology, 71, pp. 103–111, 2021.
  • Carlsen, Maria Lyngby, Bruhn, Dennis S., Pezeshkian, Weria, Khandelia, Himanshu. Long chain sphingomyelin depletes cholesterol from the cytoplasmic leaflet in asymmetric lipid membranes. RSC Advances, 11, pp. 22677–22682, 2021.
  • Pezeshkian, Weria, Ipsen, John H.. Creasing of flexible membranes at vanishing tension. Phys. Rev. E, 103, pp. L041001, 2021.
  • Pezeshkian, Weria, Shillcock, Julian C., Ipsen, John H.. Computational approaches to explore toxin entry into the host cell. Toxins, 13, pp. 449–455, 2021.
  • Arumugam, Senthil, Schmieder, Stefanie, Pezeshkian, Weria, Becken, Ulrike, Wunder, Christian, Chinnapen, Dan, et al.. Ceramide structure dictates glycosphingolipid nanodomain assembly and function. Nature Communications, 12, pp. 3675, 2021.
  • Liu, Yang, De Vries, Alex, Pezeshkian, Weria, Marrink, Siewert J.. Capturing membrane phase separation by dual resolution molecular dynamics simulations. J. Chem. Theory Comput., 17, pp. 5876–5884, 2021.
  • Florentsen, Christoffer D., Kamp-Sonne, Alexander, Moreno-Pescador, Guillermo, Pezeshkian, Weria, Zanjani, Ali Asghar Hakami, Khandelia, Himanshu, et al.. Annexin A4 trimers are recruited by high membrane curvatures in Giant Plasma Membrane Vesicles. Soft Matter, 17, pp. 308–318, 2021.

2020

  • Liu, Yang, de Vries, Alex H., Barnoud, Jonathan, Pezeshkian, Weria, Melcr, Josef, Marrink, Siewert J.. Dual Resolution Membrane Simulations Using Virtual Sites. J. Phys. Chem B, 124, pp. 3944–3953, 2020.
  • Liu, Yang, Pezeshkian, Weria, Barnoud, Jonathan, de Vries, Alex H., Marrink, Siewert J.. Coupling Coarse-Grained to Fine-Grained Models via Hamiltonian Replica Exchange. J. Chem. Theory Comput., 16, pp. 5313–5322, 2020.
  • Pezeshkian, Weria, König, Melanie, Wassenaar, Tsjerk A., Marrink, Siewert J.. Backmapping triangulated surfaces to coarse-grained membrane models. Nature Communications, 11, pp. 2296, 2020.

2019

  • Pezeshkian, Weria, Ipsen, John H.. Fluctuations and conformational stability of a membrane patch with curvature inducing inclusions. Soft Matter, 15, pp. 9974–9981, 2019.
  • Pezeshkian, Weria, König, Melanie, Marrink, Siewert J., Ipsen, John H.. A Multi-Scale Approach to Membrane Remodeling Processes. Front. Mol. Biosci., 6, pp. 59–66, 2019.

2018

  • Pezeshkian, Weria, Guillaume Chevrot, Himanshu Khandelia. The role of Caveolin-1 in Lipid Droplets and their Biogenesis. Chem. Phys. Lipids, 211, pp. 93–99, 2018.
  • Pezeshkian, Weria, Khandelia, Himanshu, Marsh, Derek. Lipid Configurations from Molecular Dynamics Simulations. Biophys. J, 114, pp. 1895–1907, 2018.
  • Olesen, Karina, Awasthi, Neha, Bruhn, Dennis S., Pezeshkian, Weria, Khandelia, Himanshu. Faster Simulations with a 5 fs Time Step for Lipids in the CHARMM Force Field. J. Chem. Theory Comput., 14, pp. 3342–3350, 2018.
  • Johannes, Ludger, Pezeshkian, Weria, Ipsen, John H., Shillcock, Julian C.. Clustering on Membranes: Fluctuations and More. Trends Cell Biol., 28, pp. 405–415, 2018.
  • Courtney, K., Pezeshkian, Weria, Raghupathy, R., Zhang, C., Ipsen, J. H., Ford, D., et al.. C24 Sphingolipids Govern the Transbilayer Asymmetry of Cholesterol and Lateral Organization of Model and Live-Cell Plasma Membranes. Cell reports, 24, pp. 1037–1049, 2018.
  • Boye, Theresa L., Jeppesen, Jonas C., Maeda, Kenji, Pezeshkian, Weria, Solovyeva, Vita, Nylandsted, Jesper, et al.. Annexins induce curvature on free-edge membranes displaying distinct morphologies. Sci. Rep., 8, pp. 10309, 2018.

2017

  • Ali-Doosti, Baharan, Pezeshkian, Weria, Bruhn, Dennis S., Ipsen, John H., Khandelia, Himanshu, Jeffries, Gavin D. M., et al.. Membrane tubulation in giant lipid vesicles triggered by the local application of calcium ions. Langmuir, 33, pp. 11010–11017, 2017.
  • Pezeshkian, Weria, Gao, Haifei, Arumugam, Senthil, Becken, Ulrike, Bassereau, Patricia, Florent, Jean-Claude, et al.. Mechanism of Shiga Toxin Clustering on Membranes. ACS Nano, 11, pp. 314–324, 2017.
  • Pezeshkian, Weria, Nåbo, Lina J., Ipsen, John H.. Cholera Toxin B subunit induces local curvature on lipid bilayers. FEBS Open Bio., 7, pp. 1638–1645, 2017.
  • Boye, Theresa L., Maeda, Kenji, Pezeshkian, Weria, Sønder, Stine L., Haeger, Swantje C., Gerke, Volker, et al.. Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair. Nature Communications, 8, pp. 1623, 2017.

2016

  • Pezeshkian, Weria, Hansen, Alan G., Johannes, Ludger, Khandelia, Himanshu, Shillcock, Julian C., Kumar, P. B. Sunil, et al.. Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation. Soft Matter, 12, pp. 5164–5171, 2016.

2015

  • Pezeshkian, Weria, Chaban, Vitaly V., Johannes, Ludger, Shillcock, Julian, Ipsen, John H., Khandelia, Himanshu. The effects of globotriaosylceramide tail saturation level on bilayer phases. Soft Matter, 11, pp. 1352–1361, 2015.

2012

  • Pezeshkian, Weria, Nikoofard, Narges, Norouzi, Davood, Mohammad-Rafiee, Farshid, Fazli, Hossein. Distribution of counterions and interaction between two similarly charged dielectric slabs: Roles of charge discreteness and dielectric inhomogeneity. Phys. Rev. E, 85, pp. 061925, 2012.